Interactions of the Striatal Gene Rhes with the Dopaminergic System in Rodents
نویسنده
چکیده
Acknowledgment I want to give thanks to my mother, father, sisters and brothers for their permanent support, motivation, enthusiasm, and guidance on my life. I want to thank also to SENACYT and IFARHU who gave me the opportunity to study for an advanced degree in a prestigious international institution. I would also express my gratitude to Dr. Gerald J LaHoste for his professionalism, guidance and motivation as mentor in this study. I want to thank Dr. their technical help in this study. Finally, I want to thank all my professors for being an invaluable source of knowledge and opportunity, and the administrative staff at the Department of Psychology for their professionalism and motivation.
منابع مشابه
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons.
Rhes is a small GTP-binding protein prominently localized in the striatum. Previous findings obtained in cell culture systems demonstrated an involvement of Rhes in cAMP/PKA signalling pathway, at a level proximal to the activation of heterotrimeric G-protein complex. However, its role in the striatum has been, so far, only supposed. Here we studied the involvement of Rhes in dopaminergic signa...
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In rodent and human brains, the small GTP-binding protein Rhes is highly expressed in virtually all dopaminoceptive striatal GABAergic medium spiny neurons, as well as in large aspiny cholinergic interneurons, where it is thought to modulate dopamine-dependent signaling. Consistent with this knowledge, and considering that dopaminergic neurotransmission is altered in neurological and psychiatri...
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Huntington's disease (HD) is caused by an expansion of glutamine repeats in the huntingtin protein (mHtt) that invokes early and prominent damage of the striatum, a region that controls motor behaviors. Despite its ubiquitous expression, why certain brain regions, such as the cerebellum, are relatively spared from neuronal loss by mHtt remains unclear. Previously, we implicated the striatal-enr...
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Although the mutated protein causing Huntington's disease (HD) is expressed throughout the body, the major pathology of HD is localized to the striatum of the brain. We previously reported that the striatal-enriched protein Rhes binds the mutated huntingtin protein and enhances its cytotoxicity. We now demonstrate that Rhes-deleted mice are dramatically protected from neurotoxicity and motor dy...
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Mechanisms of gender-specific synaptic plasticity in the striatum, a brain region that controls motor, cognitive and psychiatric functions, remain unclear. Here we report that Rhes, a GTPase enriched in medium spiny neurons (MSNs) of striatum, alters the striatal cAMP/PKA signaling cascade in a gender-specific manner. While Rhes knockout (KO) male mice, compared to wild-type (WT) mice, had a si...
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